Method for the characterization of the three-dimensional structure of proteins employing mass spectrometric analysis and computational feedback modeling

摘要

A method for characterizing the three-dimensional surface structure of molecules, particularly proteins and protein complexes, employing mass spectrometric analysis, an electrospray ionization (ES) source, a novel data interpretation process that utilizes comparisons of particular binding constants (K_B) and heats of formation (ΔH_f), and computational feedback modeling.