首页> 外国专利> Method for treatment and repair of meniscal injuries

Method for treatment and repair of meniscal injuries

机译：半月板损伤的治疗和修复方法

页面导航

摘要
著录项
相似文献

摘要

A method for repair of meniscal injuries comprising induction of meniscal regeneration by introducing a strongly adhesive collagen-polyethylene glycol (PEG) hydrogel to a site of injury.

机译：一种用于修复半月板损伤的方法，该方法包括通过将强粘性的胶原蛋白-聚乙二醇（PEG）水凝胶引入损伤部位来诱导半月板再生。

著录项

公开/公告号US7157428B2

专利类型
公开/公告日2007-01-02

原文格式PDF
申请/专利权人 AKIHIKO KUSANAGI;MARY BETH SCHMIDT;LAURENCE J. B. TARRANT;
展开▼

申请/专利号US20040998230
发明设计人 LAURENCE J. B. TARRANT;AKIHIKO KUSANAGI;MARY BETH SCHMIDT;
展开▼

申请日2004-11-26
分类号A61K38/39;C07K14/78;
国家 US
入库时间 2022-08-21 21:00:01

相似文献

专利
外文文献
中文文献

1. Peripheral nerve repair:a hot spot analysis on treatment methods from 2010 to 2014 [J] . Guang-yao Liu, Yan Jin, Qiao Zhang, 中国神经再生研究（英文版） . 2015,第006期

2. Advantages of Dextrose, Platelet Rich Plasma and Stem Cells over the Traditional Conventional Methods in Treatment of Sports Injuries and Joint Osteoarthritis [J] . Dina, Mohamed, Ibrahim, 运动科学：英文版 . 2017,第002期

3. Umbilical cord-derived mesenchymal stem cell transplantation combined with hyperbaric oxygen treatment for repair of traumatic brain injury [J] . Hai-xiao Zhou, Zhi-gang Liu, Xiao-jiao Liu, 中国神经再生研究（英文版） . 2016,第001期

4. TREATMENT OF MENISCAL INJURIES IN THE KNEE [C] . Kevin Kaplan Proceedings of the 4th frontiers in biomedical devices conference and exposition 2009 . 2009

5. Targeting acute phosphatase PTEN inhibition and investigation of a novel combination treatment with Schwann cell transplantation to promote spinal cord injury repair in rats. [D] . Walker, Chandler L. 2013

6. Novel flat and wide meniscal repair material improves the ultimate load of knot breakage in a porcine trans-capsular meniscal repair model [O] . Hiroyuki Yokoi, Tatsuo Mae, Ryo Iuchi, 2017

7. Arthroscopic repair of the meniscal injury using meniscal repair device [O] . Tang Hengtao, Su Xuntong 2015

8. Cell Based Meniscal Repair Using an Aligned Bioactive Nanofibrous Sheath. [R] . Rothrauff, B., Tuan, R. 2017

1. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004）（P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期

2. Selected suitable seed cell, scaffold and growth factor could maximize the repair effect using tissue engineering method in spinal cord injury [J] . Wen-Chen Ji ,Xiao-Wei Zhang ,Yu-Sheng Qiu . 世界实验医学杂志 . 2016,第3期

3. 关节镜下成形联合修复缝合术治疗不稳定型外侧盘状半月板损伤疗效观察 [C] . 胡滨 ,刘宁 ,梁振雷 . 第一届中国·嵩山骨科高峰论坛暨河南省中西医结合学会2016年骨科年会 . 2016

4. 不同方法缝合修复与修整成形半月板损伤的生物力学研究 [A] . 赵晓伟 . 2013