Tetrahidropiridoazepin - 8 - onas as modulators of dopamine D2 receptor and related compounds for the treatment of Schizophrenia and other CNS disorders, Pharmaceutical compositions containing them and their use in the preparation of medicines.

摘要

Pharmaceutical ingredients containing these compounds and their use in the treatment of NCRE disorders and other disorders. Item 1: a formula compound (1) a salt acceptable from a drug, wherein G is a group of formulas selected from formula (2) or formula (3), where a is - (CH2) MH2 -.- (CH2) mO- o - (CH2) mNH-Where m is an integer from 3 to 5, in which two atoms of C - (CH2) MH2 are selectively linked by a double bond, and one or two atoms of C or N - (CH2) MH2,-(CH2) Mo-Y - (CH2) MNH - can be replaced by methyl or ethyl alone; D is n, C or CH, provided that when D is n, each atom from C to D is connected through a simple link; J and K are selected independent of N, CH and C; Q, y and Z are selected independent of N or C; The choice of V and W is independent of N, C or CH; AA ring is a saturated or unsaturated carbon cycle composed of 5, 6 or 7 members, in which one, two or three C atoms that are not shared with arilo cycles of 6 members (2) in AA ring can be replaced by N atoms arbitrarily and independently. That's it.R2 and R3 are independently selected from H, halo, cyano, hydroxy, C1-4 alkyl and C1-4 alkoxy, wherein the C1-4 alkyl or C1-4 alkoxy moieties are linear or branched and may be optionally substituted with one to three fluoro atoms and may also be optionally substituted with an amino or hydroxy substituent, provided that when Q is N, R1 is absent and when Y is N, R2 is absent; R4, R5, R6, R7, R8, and R9 are independently selected from H, fluoro, hydroxy, C1-4 alkyl and C1-4 alkoxy, wherein the C1-4 alkyl or C1-4 alkoxy moieties are linear or branched; provided that when it is N, R8 cannot be fluoro or hydroxyl,When Z is n, R9 is not present; R10 is an independent choice independent of H, C1-4 and alcoxi 1-4, in which case, C1-4 or alcoxi C1-4 asphalt macadam is linear or branched; R11, R12, R13, R14 and R15 are selected without considering h, halo, (= O) CH3, C1-4 asphalt and alcoxi-4, arilo and ariloxi, in which all debris contains asphalt. Among C1-4, C1-4 and C (= O) CH3 tar groups and arilo and ariloxi residues, one to three fluorine atoms can be used as alternatives, or aminobenzene or hydrogen Xi can be used as alternatives; R16 and R17 are independent of H, halo, Ciano, oxo, hidroxi - (= O) CH3.C1-4 and alcox C1-4, in which the residues of C1-4, C1-4 and - C (= O) CH3 tar group can be replaced by one to three fluorine atoms or one or more amino or hydroxyl substitutes.