glycoimidazole and polyhydroxycyclohexenyl compound and method for synthesizing glycoimidazole and polyhydroxycyclohexenyl compound, methods for inhibiting glucocerebrosidase, for enhancing glucocerebrosidase activity, pharmaceutical composition, methods for inhibiting a -glycosity, and for treating gaucher disease, glycoimidazole and polyhydroxycyclohexylamine derivatives

摘要

"COMPOUND AND GLICOIMIDAZOL POLIHIDROXICICLOHEXENILA AND METHOD FOR SYNTHECIZE COMPOUND AND GLICOIMIDAZOL POLIHIDROXICICLOHEXENILA, METHODS FOR INHIBITING GLICOCEREBROSIDADE, TO INCREASE glucocerebrosidase ACTIVITY AND STABILIZING GLICOCEREBROSIDADE, PHARMACEUTICAL COMPOSITION, METHODS FOR INHIBITING A 225 -glycosidase, AND TO TREAT THE DISEASE GAUCHER, Glycoimidazole derivative and polyhydroxycyclohexylamine derivatives ". The present invention provides glycoimidazole (GIZ) and polyhydroxycyclohexenyl amine (PHCA) derivatives, methods for their manufacture, and methods of use wherein the GIZ and PHCA derivatives have a short flexible binder from the corresponding position of oxygen in the ring in a pyranose; and a lipophilic moiety attached to the binder and pharmaceutically acceptable salts thereof. More particularly, the present invention further relates to a method of treating individuals with Gaucher disease by administering the novel GIZ and PHCA derivatives as chaperones (linker proteins) for the disease-associated mutant glucocerebrosidase.