method of combating toxicity caused by an antifolate compound, and of treating a disease, uses enzyme having carboxy-peptidase g activity, antifolate compound, folate route rescue agent, and enzyme having carboxide activity. peptidase g and a folate route rescue agent, therapeutic system, and ex vivo method of cleaving a terminal 1-glutamate group of a compound, determining the rate and / or extent of cleavage of a compound, and cleavage of a compound

摘要

"METHODS OF COMBATING TOXICITY CAUSED BY AN ANTI-FOLATE COMPOUND, AND TREATING A DISEASE, USES OF ENZYME ACTIVITY, CARBIO-PEPTIDASE G ACTIVITY, FOLATE ROTATE RESPONSE AGENT, AND AXIS DEX DEEP CARE GE OF A FOLATE ROUTE RESCUE AGENT, THERAPEUTIC SYSTEM, AND EX VIVO METHODS OF CLIVING A COMPOSIUM L-GLUTAMAT GROUP, DETERMINING THE RATE AND / OR CLOSING EXTENSION OF A COMPOUND, AND "A method of combating toxicity caused by an antifolate compound of Formula (1) in an individual who has been administered with the compound. The method comprises administering to the subject an enzyme which has carboxy peptidase G activity. A method of cleaving a compound comprising a structural fragment of Formula (VIII) the method comprising contacting the compound comprising the structural fragment of Formula (VIII) with a enzyme that has G-carboxy peptidase activity.