compound or a pharmaceutically acceptable salt, hydrate, or solvate thereof, pharmaceutical composition, and methods for the prophylaxis or treatment of disease, for reducing an individual's food intake, for inducing satiety in an individual, for controlling or reducing gain of weight in an individual, to modulate a mch receptor in an individual and to produce a pharmaceutical composition

摘要

"COMPOUND OR A HYDRATE SALT, OR PHARMACEUTICALLY ACCEPTABLE SOLVAT OF THE SAME, PHARMACEUTICAL COMPOSITION, AND, METHODS FOR PROPHYLAXY OR TREATMENT, TO REDUCE INGESTION OF AN INDIVIDUAL OR INDIRECT INDIVIDUAL SIDE OF WEIGHT IN AN INDIVIDUAL, TO MODULATE A MCH RECEIVER IN AN INDIVIDUAL AND TO PRODUCE A PHARMACEUTICAL COMPOSITION "The present invention comprises novel (pyridine) substituted pyrimidine compounds which act as MCH receptor antagonists. These compounds are useful in pharmaceutical compositions whose use includes prophylaxis or the treatment of improving memory, sleep and wake function, anxiety, depression, mood disorders, seizures, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, compulsive eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive impairment, substance abuse disorder and dyskinesias including Parkinson's disease , epilepsy, and addiction.