phenotype identification method, single cell, agent identification methods, agents, therapeutic agents, therapeutic agent evaluation method, pharmaceutical composition, treatment methods, dysfunction prevention or amelioration and modulation methods

摘要

PHENOTYPE IDENTIFICATION METHOD, ISOLATED CELL, AGENT IDENTIFICATION METHODS, AGENTS, THERAPEUTIC AGENTS EVALUATION METHOD, PHARMACEUTICAL COMPOSITION, METHODOLOGY The present invention relates to transgenic animals as well as compositions and methods relating to the characterization of genetic function. Specifically, the present invention provides transgenic mice comprising disruptions in the genes PRO256, PRO34421, PRO334, PRO770, PRO983, PRO1009, PRO1107, PRO1158, PRO1250, PRO1317, PRO4334, PRO4395, PRO49192, PRO9799, PRO21175, PRO19837, PRO2139 or PRO1480. These in vivo studies and characterizations may provide valuable identification and discovery of therapeutic products and / or treatments useful in the prevention, amelioration or correction of diseases or disorders associated with genetic disruptions, such as neurological disorders; cardiovascular, endothelial or angiogenic dysfunctions; eye abnormalities; immune dysfunctions; cancer dysfunctions; metabolic dysfunctions or abnormalities of bones; metabolic dysfunctions in lipids; or developmental abnormalities.