A PROCESS OF PREPARING LARGE CRYSTALS OF ZIPRASIDONE HYDROCHLORIDE MONOHYDRATE

摘要

A process of preparing large crystals of ziprasidone hydrochloride monohydrate, comprising the steps of: 1) dissolving ziprasidone free base in a solvent comprising THF and water, in a volume ratio of about 22- 35 unit volumes of THF to about 1.5-8 volumes of water; 2) heating the solution resulting from step (1); 3) adding HC1 to the solution resulting from step (2); and 4) cooling the solution resulting from step (3).