6-synthesis method of ethnic minority derivatives

摘要

It refers to a preparation procedure, including: (a) combining a third-order anion with a seventh-order acid to obtain the second; (b) combining the second-order unprotected state to obtain the first-order preparation compound; in the first-order, X is the cyclopropyl compound C3-C7, substituting or not substituting, bicycle or heteromorphic arilo 8-12 ATOMOS, including 1-4 heterocompounds selected from n, S, or, among others; V is ethylene, acetylene; PG is an ammonia protection group; R4 is C1-C6 tar; Z is NH, N - (C1-C6 tar);R1, G2 and R3 are h, halogen, C1-C6 and alquenilo C2-C6, respectively; n is 0-1; X is 0-3; y is 0-1; Z is 0-3. A compound obtained by this process is: (E) n - {4 - [3-chloro-4 - (2-pyridylmethyl ether) anilino] 3-cyano-7-etoxi-6-quinlinil} - 4 - (methylamine) - 2-butadiene, which is effective in cancer treatment.