NOVEL TETRACYCLIC ANALOGUES OF CAMPTHOTECTIN, METHODS OF OBTAINING THEM AS MEDICAL AGENTS AND PHARMACOLOGICAL COMPOSITIONS CONTAINING SUCH ANALOGUES

摘要

The invention relates to new tetracyclic analogues of camptothecin, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them. Said analogues, which include in particular 3-hydroxy-3-(4-oxo-4,6-dihydroindolizino [1,2-b] quinoline-2-yl)pentanoic acid, have a powerful biological activity inhibiting topoisomerase I and/or topoisomerase II.