NEW LIGANDS THAT ARE ANTAGONISTS OF RAR RECEPTORS, PROCEDURE FOR PREPARATION OF THESE LIGANDS AND USE OF THESE LIGANDS IN THE FIELD OF HUMAN MEDICINE AND COSMETICS.

摘要

Compounds, characterized by responding to the following formula (I): (See formula) where: - A represents CHOH, C = O or a selenium atom; - B is selected from formulas (a) to (f): (See formula) where Ar is defined as follows: - Ar is selected from formulas (g) through (i): (See formula) where R3 is as define below; - R1 represents a radical -OH, -OR4, -NHR5 or NR5R6, where R4, R5 and R6 are as defined below; - R2 represents a hydrogen, fluorine, chlorine or bromine atom, a linear or branched alkyl radical of 1 to 5 carbon atoms, a radical CF3, OR7, SR7, NHR8, NR8R9, 2-naphthyl, 2-pyridyl, 3- pyridyl, 4-pyridyl, 2-thiophenyl, CH2OR10 or CH2NR11R12, or a phenyl radical unsubstituted or substituted with at least one fluorine atom or a methyl, ethyl, isopropyl, tert-butyl or CF3 radical, where R7, R8, R9 , R10, R11 and R12 as defined below; - R3 represents a hydrogen, fluorine or chlorine atom or an OH, OR13, CF3 or NR14R15 radical.