SYSTEM AND METHOD FOR CLEANING NOISY GENETIC DATA AND USING GENETIC, PHENTOYPIC AND CLINICAL DATA TO MAKE PREDICTIONS

摘要

A system and method for determining the genetic data for one or a small set ofcells, or from fragmentary DNA, where a limited quantity of genetic data isavailable, and also for predicting likely phenotypic outcomes usingmathematical models and given genetic, phenotypic and/or clinical data of anindividual, and also relevant aggregated medical data consisting of genotypic,phenotypic, and/or clinical data from germane patient subpopulations. Geneticdata for the target individual is acquired and amplified using known methods,and poorly measured base pairs, missing alleles and missing regions arereconstructed using expected similarities between the target genome and thegenome of genetically related subjects.