INFLUENZA INFECTION-INHIBITING PEPTIDE, INFLUENZA VIRUS-INFECTION INHIBITOR, LIPOSOME AND INFLUENZA PREVENTIVE/THERAPEUTIC AGENT

摘要

The object is to provide a peptide having higher affinity to hemagglutinin, a peptide having a high inhibitory activity on the infection with an influenza virus, and a pharmaceutical composition comprising any one of the peptides. Peptides having a mutation in the sequence: ARLSPTMVHPNGAQP (peptide A-1; SEQ ID NO:1) are prepared, and screening is made for a peptide having higher affinity to hemagglutinin. As a result, polypeptides comprising the sequences depicted in SEQ ID NOs:2-7, 9-10 and 12-18 can be obtained. These peptides can be used as the peptide mentioned above. In a peptide having the sequence depicted in SEQ ID NO:3, when the C-terminus of the sequence of SEQ ID NO:3 is removed so as to allowing ARLPR or ARLP to remain, the inhibitory activity of the peptide on the infection with an influenza virus can be increased. An inhibitor of the infection with an influenza virus or a prophylactic/therapeutic agent for influenza can be prepared by formulating the above-mentioned influenza virus receptor-binding peptide.