CELLULAR FUNCTION UNDERLYING BONE MICRO-STRUCTURE CHARACTERISTIC OF TYPE 2 DIABETES

摘要

The present invention relates to methods of characterizing and modifying bone quality and pathogenesis in patients suffering from bone pathologies, including those associated with metabolix disorders such as Type 2 diabetes. These methods may involve increasing bone density and/or thickness, as necessary in the patient, and reducing bone tissue degradation as, for instance, due to type 2 diabetes. The methods of the present invention may applied to cortical and/or cancellous bone.