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HOST CELL EXPRESSING REDUCED LEVELS OF A METALLOPROTEASE AND METHODS USING THE HOST CELL IN PROTEIN PRODUCTION
HOST CELL EXPRESSING REDUCED LEVELS OF A METALLOPROTEASE AND METHODS USING THE HOST CELL IN PROTEIN PRODUCTION
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机译:表达金属蛋白酶的宿主细胞水平降低以及在蛋白生产中使用宿主细胞的方法
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摘要
The present invention relates to novel host cells and to methods of producing proteins. More specifically the invention relates to a host cell useful for the expression of heterologous proteins, which host cell has been genetically modified in order to express significantly reduced levels of a metalloprotease. Moreover the invention relates to a method of producing a heterologous protein, which method comprises cultivating the host cell in a suitable growth medium, followed by recovery of the desired protein.
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