OLIGORIBONUCLEOTIDE SEQUENCE HOMOLOGOUS TO A CDNA REGION WHICH CODES FOR THE HUMAN CD40 RECEPTOR AND DUPLEX OLIGORIBONUCLEOTIDES, VECTORS, PHARMACEUTICAL COMPOSITIONS AND USES ASSOCIATED THERETO

摘要

The invention relates to an oligoribonucleotide sequence homologous to a region of cDNA coding for the human CD40 receptor and duplex oligoribonucleotides , vectors, pharmaceutical compositions and corresponding uses, namely to the oligoribonucleotide sequences 5'-gcgaauuccuagacaccug-3'and 5'-caggugucuaggaauucgc-3' which are homologous to the region comprised between the nucleotides 241 to 259 in the cDNA coding for the human CD40 receptor, as per GeneBank accession number X60592, as well as sequences and duplex oligoribonucleotides derived therefrom. It also relates to pharmaceutical compositions comprising them, to gene transfer vectors capable of inducing their expression, and their use in the preparation of medicaments, for example, for the inhibition of the expression of the human CD40 receptor, for the blockade or reduction of the human CD40-CD40L interaction, etc.