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NOVEL EFFICIENT PROCESS FOR PRODUCTION OF CAPSULAR POLYSACCHARIDES OF PATHOGENIC GRAM-POSITIVE BACTERIA BY HETEROLOGOUS EXPRESSION AND SECRETION OF COMPLEX POLYSACCHARIDES IN NON-PATHOGENIC, NON-INVASIVE GRAM-POSITIVE BACTERIA
NOVEL EFFICIENT PROCESS FOR PRODUCTION OF CAPSULAR POLYSACCHARIDES OF PATHOGENIC GRAM-POSITIVE BACTERIA BY HETEROLOGOUS EXPRESSION AND SECRETION OF COMPLEX POLYSACCHARIDES IN NON-PATHOGENIC, NON-INVASIVE GRAM-POSITIVE BACTERIA
The current invention provides methods and means for heterologous expression, production and/or secretion of complex capsular polysaccharides in non-pathogenic, non-invasive Gram-positive bacteria. The invention in particular provides non-pathogenic, non-invasive Gram-positive bacteria capable of expression and/or secretion of heterologous, complex polysaccharides from a pathogenic bacterial species. Such bacteria and polysaccharides produced therein may be applied according to the invention to provide compositions for vaccination for the treatment and prevention of infectious bacterial diseases.
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