A Genotyping Kit for Surgical Operation of Paclitaxel Eluting Stent

摘要

The present invention relates to a genotyping kit comprising a DNA chip and an electric DNA chip capable of analyzing the genetic polymorphisms of the MDR1 gene and the MRP2 gene. The kit for genotyping of the present invention comprises (i) a gene probe capable of specifically binding to the MDR1 gene and MRP2 gene of a human having a specific genetic polymorphism, and having a nucleotide sequence of SEQ ID NOs: 43 to 48; A linker comprising oligo (dT) ₁₅ ,-(CH ₂ ) ₆ -and an amine group sequentially, wherein the 5 ′ end of the electric gene probe is connected to the 3 ′ end of oligo (dT) ₁₅ ; And a aldehyde bonded to the surface, and a solid-state DNA chip comprising a solid in which an amine group of the electric linker is linked through a aldehyde group on the surface and a Schiff's base reaction; And, (ii) fluorescently labeled deoxy nucleotides for labeling the cDNA synthesized from RNA taken from the sample. If the kit for genotyping of the present invention can predict in advance whether vascular restenosis will occur in a patient who has undergone a paclitaxel release stent, the kit may be widely used for a safer stent procedure.;MDR1 gene, MRP2 gene, DNA chip, genotyping kit