COMPOSITION COMPRISING COMPOUND SCE25-20 ISOLATED FROM SAURURUS CHINENSIS FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY, ALLERGY OR BLOOD CIRCULATORY DISEASES

摘要

A composition for the prevention and treatment of inflammatory, allergy or blood circulatory diseases comprising a SCE25-20 compound isolated from Saururus chinensis is provided to inhibit activity of 5-lipoxygenase causing allergy and asthma, production of cyclooxygenase-2 dependent prostaglandin D2, degranulation in mast cell, production of nitric oxide radical, expression of iNOS(inducible nitric oxide synthase), and activity of MMP-9(matrix metalloproteinase-9) associated with arteriosclerosis and vascular diseases. The composition for the prevention and treatment of inflammatory, allergy or blood circulatory diseases comprises 0.01-99.9%, preferably 0.1-90% of the SCE25-20 compound isolated from Saururus chinensis, represented by the formula(1) which is prepared by cutting roots, leaves or stems of Saururus chinensis, extracting the fragments of Saururus chinensis with a solvent selected from water, C1-C4 lower alcohol such as methanol at 20-30 deg.C for 1 hour to 10 days, filtering and concentrating the extract of Saururus chinensis under reduced pressure; fractionating the Saururus chinensis extract with n-hexane, ethylacetate, n-butanol and water, sequentially, and subjecting the fraction to chromatography.