Use of naphthalene derivatives for the treatment of hyperaldosteronism, heart failure, myocardial fibrosis, hypercortisolismus, diabetes mellitus, depression, metabolic syndromes and age-related cognitive decline

摘要

Use of naphthalene derivatives (I) or their salts for the treatment of hyperaldosteronism, heart failure, myocardial fibrosis, hypercortisolismus, diabetes mellitus, depression, metabolic syndromes and age-related cognitive decline. Use of naphthalene derivatives of formula (I) or their salts for the treatment of hyperaldosteronism, heart failure, myocardial fibrosis, hypercortisolismus, diabetes mellitus depression, metabolic syndromes and age-related cognitive decline. Y 1(=C(R 9) 2), (=N(R 10)), (=O) or (=S); T 1, U 1, V 1, W 1, X 1C or N; R 1, R 2H, halo, CN, OH, nitro, alkyl, alkoxy, alkyl carbonyl, alkylcarbonyloxy, alkylaminocarbonyl, alkylaminosulfonyl, thioalkyl, alkylsulfinyl or alkyl sulfonyl; R 3nitrogenous mono- or bicyclic heteroaryl residue (where partially or completely saturated equivalents and substituted) and N atom which is not substituted; R 4-R 9H, halo, CN, OH, nitro, lower alkyl, lower alkoxy, lower alkylcarbonyl, lower alkylcarbonyloxy, lower alkylaminocarbonyl, lower alkyaminosulfonyl, lower thioalkyl, lower alkylsulfinyl, lower alkylsulfonyl, arylalkyloxy, heteroarylalkyloxy; and n : 0-2. With provisos. Full definitions are given in the DEFINITIONS (Full Definitions) Field. [Image] ACTIVITY : Cardiant; Antiinflammatory; Antidiabetic; Antidepressant; Analgesic; Antianginal; Nootropic. MECHANISM OF ACTION : Mammalian-cytochrome-P450 (CYP)-oxygenase inhibitor; Human or mammalian-aldosterone synthase inhibitor; Steroid-11beta -hydroxylase inhibitor. The CYP11B2 inhibitory activity of (I) was tested in cell line using biological assays. The results showed that (I) exhibited a median inhibitory concentration value of 92%.