Use of an exogenous or endogenous inhibitor of N-methyltransferase for the manufacture of a medicament for therapy and prophylaxis of Parkinson's syndrome

摘要

Exogenous or endogenous inhibitors of N-methyltransferase are used for the manufacture of a medicament for therapy and prophylaxis of Parkinson's syndrome. ACTIVITY : Antiparkinsonian. MECHANISM OF ACTION : N-methyltransferase inhibitor. A tripeptide, Ala-Cys-Cys, isolated from rabbit liver, was tested to inhibit phenylethanolamine-N-methyltransferase (PNMT) using biological assays. The results showed that the tripeptide exhibited inhibitory activity of 90%.