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Silicone elastomer containing homogeneously dispersed, micronized antiseptic, e.g. chlorhexidine, octenidine or triclosan, used for the production of plastic medical articles, especially catheters
Silicone elastomer containing homogeneously dispersed, micronized antiseptic, e.g. chlorhexidine, octenidine or triclosan, used for the production of plastic medical articles, especially catheters
Silicone elastomers (SE) containing a homogeneously dispersed antiseptic with an average particle size (d50) of 0.5-15 (preferably 1-10) microns and a particle size distribution of 0.1-30 (preferably 0.5-20) microns. Independent claims are included for (1) catheters containing SE as above (2) silicone rubber formulations (SRF) containing (A) polysiloxane(s) of formula R 1(R 2) 2SiO(SiR 3R 4O) xSiR 1(R 2) 2 (I), (I) polyhydrogen-siloxane(s) of formula R 21(R 22) 2SiO(SiR 23R 24O) xSiR 21(R 22) 2 (II), (J) catalyst(s) containing a platinum group metal and not more than 3 parts by weight (pts. wt.) other metal compounds (oxides, carbonates, other salts or complexes of Fe, Al, Zn, Ti, Zr, Ce or other lanthanoids) to 100 pts. wt. (A), and (K) at least one suspension of antiseptic(s) (especially chlorhexidine, octenidine, PHMB, Quats, taurolidine and/or triclosan) in (I) and/or (II) and/or non-functional siloxanes (G) (3) a method for the production of SE by polymerising SRF as defined above. R 1, R 21-12C alkyl or fluoroalkyl, or optionally substituted phenyl or naphthyl; R 3, R 4as for R 1/R 2, but also -OSiR 2R 3R; R : a continuation of the siloxane chain indicating a branch, so that the polymer contains branching units of formula SiO 4/2 and R 3SiO 3/2; R 1 and R 3may also be 1-12C alkenyl groups, with the polymer containing 0.0002-3 wt% vinyl groups and at least two olefinic double bonds per molecule; x (in (I)) : 2-15000, varied so that the polymer shows a viscosity of 0.1-1000 Pa.s at 25[deg]C; R 21, R 22as for R 1 and R 2; R 23H, or other groups as for R 1/R 2, or uOSiR 23R 24R giving branching units SiO 4/2 and R 23SiO 3/2 with R 23 = H in at least 4 of these silyldioxy units, so that one molecule has at least 4 crosslinking sites; R 24as for R 23 but not H; x (in (II)) : 4-10000, varied to give a viscosity of 0.0005-0.1 Pa.s at 25[deg]C.
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机译：含有均匀分散的防腐剂的有机硅弹性体（SE），其平均粒径（d50）为0.5-15（最好为1-10）微米，粒径分布为0.1-30（最好为0.5-20）微米。包括以下方面的独立权利要求：（1）包含上述SE的导管（2）包含（A）式R 1>（R 2>）2SiO（SiR 3> R 4> O）的聚硅氧烷的硅橡胶配方（SRF） xSiR 1>（R 2>）2（I），（I）式R 21>（R 22>）2SiO（SiR 23> R 24> O）的聚氢硅氧烷xSiR 21>（R 22>） 2（II），（J）催化剂，含铂族金属和不超过3重量份（pt。wt。）的其他金属化合物（Fe，Al，Zn的氧化物，碳酸盐，其他盐或络合物）， Ti，Zr，Ce或其他镧系元素）至100点。重量（A）和（K）在（I）和/或（II）和/或非功能性硅氧烷中的至少一种防腐剂（尤其是洗必太，辛烯定，PHMB，季铵盐，牛磺酸和/或三氯生）的悬浮液（G）（3）一种通过聚合如上定义的SRF生产SE的方法。 R 1＞，R 2＞ 1-12C的烷基或氟代烷基，或任选取代的苯基或萘基; R 3>，R 4>与R 1> / R 2>相同，而且-OSiR 2> R 3> R; R：表示支链的硅氧烷链的延续，因此聚合物含有式SiO 4/2的支链单元和R 3＞ SiO 3/2; R 1>和R 3>也可以是1-12C烯基，该聚合物每个分子含有0.0002-3重量％的乙烯基和至少两个烯属双键; x（在（I）中）：2-15000，变化，使得聚合物在25℃下显示出0.1-1000Pa.s的粘度; R 21＞，R 22＞ R 1＞，R 2＞。 R 23> H或R 1> / R 2>的其他基团，或uOSiR 23> R 24> R至少在R 23> = H时给出支链单元SiO 4/2和R 23> SiO 3/2这些甲硅烷基二氧基单元中有4个，因此一个分子具有至少4个交联位; R 24＞ R 23＞但不是H; x（在（II）中）：4-10000，变化以在25℃下获得0.0005-0.1Pa.s的粘度。
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