A flowable biomedical filler resisiting flow at higher shear stress or compressive force

摘要

A bone replacement filler comprising a biomedical ceramic particulate, wherein the filler is able to flow without the application of an external shear stress or compressive force or under a relatively low shear stress or compressive force, but resists flow or does not flow when subjected to a higher shear stress or compressive force, and wherein at least some of the particles in the ceramic particulate have a micro-porous surface structure and/or a micro-porous sub-surface structure. The filler may be provided in dry form with no liquid carrier or may be provided with pharmaceutical drugs or biologically functional peptides infiltrated in the micropores of ceramic particulates.