Compositions and uses thereof for promoting keratinocyte migration and epidermal repair via receptors comprising OSMRβ as a subunit

摘要

The present invention relates to the field of epidermal repair. More particularly, the invention concerns the use of a molecule able to act on a heteromeric receptor comprising OSMR² as a subunit, by inhibiting or activating said subunit, for the preparation of a composition for modulating in vitro and/or in vivo keratinocyte migration and/or the expression of inflammatory factors by the keratinocytes. In particular, the invention concerns the use of OSM and/or IL-31, or antagonists thereof, for the preparation of cosmetic or dermatologic compositions. Methods for obtaining in vitro or animal models of skin inflammation diseases are also disclosed. These models can be used for screening molecules to find new drugs to prevent or treat psoriasis and other dermatitis.