COMPOUND HAVING SELECTIVE OATP-INHIBITING PROPERTY, AND SELECTIVE OATP-INHIBITING AGENT CONTAINING THE COMPOUND

摘要

PROBLEM TO BE SOLVED: To provide a compound for selectively inhibiting OATP, and to provide an inhibiting agent for selectively inhibiting OATP.;SOLUTION: The compound is represented by formula 1, wherein X is a phenyl group or a biphenyl group substituted with a carboxyl group or a sulfonic group; Y is carbonyl (-CO-), sulfinyl (-SO-) or sulfonyl (-SO₂-); Z is a functional group represented by -NH(R₁) and R₁ is an alkyl, a cycloalkylaryl. The selective OATP inhibiting agent comprises the compound or its salt.;COPYRIGHT: (C)2008,JPO&INPIT