Allergenic proteins and peptides derived from cedar pollen

摘要

(57) [summary] The present invention provides a peptide isolated cedar pollen allergen CryjI. Peptide within the scope of the invention, including a T-cell epitope of at least two, preferably at least one T cell epitope of CryjI. In addition, this invention has therapeutic properties that have been increased than or equal to that part or natural allergens corresponding, but also related to the peptide was modified with the side effects were reduced. Furthermore, the invention also provides a nucleic acid sequence encoding the peptide of the invention. And treatment or diagnosis of sensitivity to cedar pollen in an individual, and also provides therapeutic compositions comprising a peptide of the invention one or more. The present invention also provides a nucleic acid sequence encoding an allergen and JunvI JunsI and JunsI protein allergens and JunvI. JunvI and JunsI is a protein allergen of cross-reactive immunity with CryjI.