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Polypeptides for Modulating Binding of Trp Channel Proteins and Trp- Associated Proteins
Polypeptides for Modulating Binding of Trp Channel Proteins and Trp- Associated Proteins
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机译:用于调节Trp通道蛋白和Trp相关蛋白结合的多肽
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摘要
This invention relates to inhibitors and modulators of the binding between a transcient receptor potential (TRP) channel protein and a TRP-associated binding protein. In particular inhibitors and modulators of the binding between the TRPM7 channel protein and PDZ-domain containing TRP-associated proteins. These modulators and inhibitors are used to control Ca2+ transport through TRPM7 channel proteins and reduce damage to mammalian cells, including brain and spinal cord cells, after ischemia or traumatic injury.
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