Method of prognosis of metastasis by detection of FRA12E fragile site within the SMRT gene/locus at chromosome 12q24

摘要

Provided are methods for prognostic prediction of metastasis. The method comprises identifying the presence or absence of a fragile site FRA12E in 12q24 at the SMRT gene locus. The presence of FRA12E in an individual can be determined in cell samples obtained from an individual by hybridization techniques such as fluorescence in situ hybridization techniques or by analyzing alterations of expression of the SMRT gene. The presence of this FRA12E is indicative of higher likelihood of metastasis than if this fragile site is absent.