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LASER CONFOCAL SCANNING MICROSCOPE AND METHODS OF IMPROVING IMAGE QUALITY IN SUCH MICROSCOPE

机译:激光共聚焦扫描显微镜及提高此类显微镜图像质量的方法

摘要

According to a first embodiment the invention provides for increasing the throughput and reducing the striping due to imperfections in the microlens and/or confocal aperture arrays of a Laser Confocal Scanning Microscope by increasing the number of repeat patterns in the microlens and confocal aperture arrays to more than one, and incorporating an intensity modulation function that ensures constant integrated image intensities at the image detector independent of the instantaneous speed of scanning. According to a second embodiment the invention provides for reducing the striping in a Laser Confocal Scanning Microscope by introducing a second galvanometer mirror such that the emitted laser light beam is descanned at the image (sample) plane. According to embodiments three to five, striping in a Laser Confocal Scanning Microscope is also reduced by destroying coherency in the emitted light beam by insertion of a small angle diffuser, by flattening the Gaussian intensity distribution of the emitted laser light beam and changing the characteristics of the beam expander. According to embodiment six the invention provides for changing the degree of confocality of a Laser Confocal Scanning Microscope by inserting a mechanism that offers a range of selectable confocal aperture sizes.
机译:根据第一实施例,本发明通过将微透镜和共焦孔阵列中的重复图案的数量增加到更多,来增加吞吐量并减少由于激光共聚焦扫描显微镜的微透镜和/或共焦孔阵列中的缺陷引起的条纹。并结合了强度调制功能,该功能可确保图像检测器处的​​恒定积分图像强度与扫描的瞬时速度无关。根据第二实施例,本发明提供了通过引入第二检流计镜来减少在激光共聚焦扫描显微镜中的条纹,使得所发射的激光束在图像(样本)平面处被去扫描。根据实施例三到五,通过插入小角度漫射器破坏发射光束的相干性,通过展平发射激光光束的高斯强度分布并改变激光的特征,还可以减少激光共聚焦扫描显微镜中的条纹。扩束器。根据实施例六,本发明通过插入提供一系列可选的共焦孔径尺寸的机构来改变激​​光共焦扫描显微镜的共焦度。

著录项

  • 公开/公告号US2008037114A1

    专利类型

  • 公开/公告日2008-02-14

    原文格式PDF

  • 申请/专利权人 JAFER SHEBLEE;KENNETH J. BELL;

    申请/专利号US20070744415

  • 发明设计人 JAFER SHEBLEE;KENNETH J. BELL;

    申请日2007-05-04

  • 分类号G02B21/06;

  • 国家 US

  • 入库时间 2022-08-21 20:14:18

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