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Monoclonal antibody for analysis and clearance of polyethylene glycol and polyethylene glycol-modified molecules
Monoclonal antibody for analysis and clearance of polyethylene glycol and polyethylene glycol-modified molecules
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机译:单克隆抗体,用于分析和清除聚乙二醇和聚乙二醇修饰的分子
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摘要
A novel anti-polyethylene glycol monoclonal antibody and its preparation are disclosed. Such an antibody can be used for determining polyethylene glycol concentration in vitro or accelerating the clearance of a polyethylene glycol containing compound from the blood circulation in the human body thereby reducing the toxicity associated with the polyethylene glycol containing conjugate. The antibody is particularly useful in cancer therapy where the therapeutic agent is selectively delivered to the tumor by increasing the tumor/blood ratio of the polyethylene glycol containing compound.
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