Derivatives of 1, 3 - dihydro imidazo 4, 5 pyridin-3 (- 2 - one as TLR7 agonist receptor, a method for their preparation, Intermediates for the synthesis of the same, which includes a Pharmaceutical Composition and its use in preparation of a Medicament for the treatment of Viral Infections.

摘要

Derivatives of 1,3 Dihydro imidazo [4,5-c] pyridin - 2 - ona as immune response Modifiers of formula (1), which Act selectively on agonist receptors similar to toii (TLR), Uses Thereof, processes for the preparation thereof, and Intermediates used in the prepared Ation of the same and compositions containing Said inhibitors.These inhibitors are useful in a variety of Therapeutic areas including the treatment of infectious diseases such as hepatitis (e.g., hepatitis, HBC), genetically related Viral Infections and cancer.Claim 1: a compound of formula (1) or a pharmaceutically acceptable Salt or solvate of the compound or tautomero, in which (a) and is a direct link, and R3 is selected from aryl, alkyl and rent C1 C1 - 6 - 4 - or c1-4 alkyl, or (b); and it is alquileno c1-4, and R3 is selected from aryl,Cycloalkyl C3 - 7 and a heterociclilo 3 to 10 members; Z is Oxygen or is absent; r1 is selected from h, halogen, Oh, CN, cycloalkyl alkyl C1 - C3 - 6, 7 - 5 alkoxy, C1, nhso2r6 nr6r7 -, -, - C (o) - co2r6, R6, nr6r7, - C (o) - C (o) nr6so2r8, aryl and heterociclilo 3 to 10 members; R2 is selected Between o H, halogen, alkyl, cycloalkyl C1 - C3 - 6, 7 - 6 - alkoxy, C1, nr6r7, co2r6 -, - C (o) nr6r7,- C (o) nr6so2r8, and heterociclilo 3 to 10 members; or R1 and R2 can be joined to form a Union type alquileno C2 - 5, incorporating such Union Option 1 or 2 heteroatoms selected each one of them independently of N, o and s is absent; R4 and R5 is selected from h, cicloalq Uilo C3 - 7, aryl, aryl, (CH2) - C (o) - co2r9, R9, rent - C1 - 6 - or - C (o) - Rent R9, C1 - 6 - or - co2r9,- C (o) - Rent nr9r10 C1 -, 6 - or - C (o) - Rent nr9r10 and C1 - 6 - or - P (o) (OH) 2; R4 and R5 is absent or is selected between R9, - C (o) - co2r9, R9, let C1 - 6 - - or - C (o) - R9, rent or co2r9 C1 - 6 - -, - C (o) - Rent nr9r10 C1 -, 6 - or - C (o) - Rent nr9r10 and C1 - 6 - or - P (o) (OH) 2, each of R6 and R7 Select independ Ientemente between C1 - 6 h, alkyl, cycloalkyl C3 - 7- Hire C1 and C3 cycloalkyl - 6 - - 7; or R6 and R7 taken together with nitrogen Heterocycles that are United to form a saturated three to six members optionally containing one or two additional heteroatoms selected from N, o and S; R8 is selected from C1 - C3 alkyl and cycloalkyl - 7 6 Faith Nile; each R9 and R10 is selected regardless of C1 - 6 h, alkyl, cycloalkyl C3 - 7Aryl, aryl and heterociclilo - (CH2) 3 to 10 members; or R9 and R10, taken together with nitrogen which are United,Form a group heterociclilo 3 to 10 members; R11 and R12 are independently selected from H and alkyl C1 - 6; or R11 and R12 along with N that are United to form a saturated heterociclilo 3 to 6 members optionally containing one or two additional heteroatoms selected from N, o and S; While these groups alkyl, cycloalkyl, alkoxy,Aryl and heterociclilo optionally substituted with one or more Atoms or groups independently selected from Halogen, Oh, CN, CF3, oxo alkyl, cycloalkyl C1 - C3 - 6, 7 - 6 - alkoxy, C1, C1 alquileno - 6 - 6 or - alkyl - C1, C1 - Rent - Oh, nr11r12, - Let C1 - 6 - nr11r12, aryl and heterociclilo 3 to 10 members; under the condition that when R1 and R2 and R5 are H and Z are absent.Then (a) is not when R4 and R3 is methyl - Ethyl; and (b) R4 is not H or Methyl and - When R3 is Methyl.