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cationic liposome stabilization method in aqueous formulations, liposome product, vaccine adjuvant, chlamydia, malaria or tuberculosis vaccine and delivery system

机译:水性制剂,脂质体产品,疫苗佐剂,衣原体,疟疾或结核病疫苗和输送系统中阳离子脂质体的稳定化方法

摘要

The method of stabilizing the caustic liposomes in aqueous formulations, liposome product, vaccine adjuvant, chlamydial vaccine, malaria or tuberculosis and the distribution system are the subject of the present invention. In particular, the present invention relates to the steric stabilization of cationic liposomes by incorporation of glycolipids into liposomes. Stabilized liposomes may be used as an adjuvant to antigenic components or as a drug delivery system. In particular, the invention relates to adjuvanted vaccines in aqueous media for immunization, wherein the final product is stable.
机译:在水性制剂,脂质体产品,疫苗佐剂,衣原体疫苗,疟疾或结核病中稳定苛性脂质体的方法和分配系统是本发明的主题。特别地,本发明涉及通过将糖脂掺入脂质体中来实现阳离子脂质体的空间稳定。稳定的脂质体可用作抗原成分的佐剂或用作药物递送系统。特别地,本发明涉及在水性介质中用于免疫的佐剂疫苗,其中最终产物是稳定的。

著录项

  • 公开/公告号BRPI0512757A

    专利类型

  • 公开/公告日2008-04-08

    原文格式PDF

  • 申请/专利权人 STATENS SERUM INSTITUT;

    申请/专利号BR2005PI12757

  • 申请日2005-07-05

  • 分类号A61K9/127;A61K39/015;A61K39/04;A61K39/118;

  • 国家 BR

  • 入库时间 2022-08-21 20:08:46

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