Method for the identification of GIP secretagogues, gastric inhibitory polypeptide, and the use of a G Protein coupled receptor to classify test compounds as secretagogues of GIP.

摘要

The present invention relates to methods of using GPR119 receptor to identify compounds useful for increasing bone mass in an individual. Agonists of GPR119 receptor are useful as therapeutic agents for treating or preventing a condition characterized by low bone mass, such as osteoporosis, and for increasing bone mass in an individual. Agonists of GPR119 receptor promote bone formation in an individual.