Compounds derived from 2.5 - Diphenyl - 1H imidazole, modulators of the activity of the Hedgehog Pathway, useful for the treatment of non melanoma Skin Cancer, psoriasis, myeloma, Lymphoma,Pancreatic cancer, prostate cancer, medulloblastoma, carcin

摘要

The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.