Solid instant-release form of administration, process for preparing such form of administration and use of therapeutic active substances when preparing such solid instant-release form of administration

摘要

In the present invention, there is disclosed a solid instant-release form of administration comprising therapeutic active substances or concentrates of active substance in an envelope composed of auxiliary substances wherein the active substances or concentrates of active substances have gel-forming properties in aqueous media such that when the active substances are dissolved in water or aqueous systems at concentrations of less than 20% they increase the viscosity of the solution to a value of more than 5 mPa.s, wherein the instant-release form has a diameter of more than 10 microns and releases active substance by more than 70 percent within a period of one hour and wherein the active substances or concentrates of the active substances are enclosed within a primary envelope formed by auxiliary substances that inhibit or compensate gel formation. There is also disclosed a process for preparing the above-described solid instant-release form of administration, said preparation process comprising mixing, granulation, spray drying, spray solidification or press granulation of active substances or concentrates of active substances with auxiliary substances being selected from the group consisting of macromolecular substances from the group consisting of sugars, salts of fatty acids, fats, waxes, surfactants, silicates or highly dispersed silicon dioxide.