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Preparation of a rapidly decaying solid composition from a solid powder and a freeze-drying step
Preparation of a rapidly decaying solid composition from a solid powder and a freeze-drying step
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机译:由固体粉末制备快速分解的固体组合物和冷冻干燥步骤
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摘要
The invention relates to a method of manufacture of fast-disintegrating solid dosage forms, characterized in that one or more structure building components in mixed solid powder form are dosed into cavities of blister packs or moulds, the remaining components dissolved in water dosed and added to the powder to form a moistened, plasticized mass, frozen to below 20° C., and the water sublimed in high vacuum. In this way solid dosage forms are obtained with a similar porous structure as usually result from freeze drying processes, but the process requires much less water, which means considerably less time and less energy.
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