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ALPHA-(ARYL-OR HETEROARYL-METHYL)-BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONISTS
ALPHA-(ARYL-OR HETEROARYL-METHYL)-BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONISTS
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机译:α-(芳基或杂芳基-甲基)-BET哌啶子丙酰胺化合物作为ORL1-受体拮抗剂
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摘要
This invention provides the compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 and R2 independently represent hydrogen or the like; R3 and R4 independently represents hydrogen or the like; R5 represents aryl or the like; -X-Y- represents -CH2O- or the like; and n represents 0, 1 or 2.These compounds have ORL1 -receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.
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机译:本发明提供了式(Ⅰ)化合物或其药学上可接受的盐,其中R 1和R 2独立地代表氢等。 R 3和R 4独立地表示氢等。 R 5表示芳基等。 -X-Y-表示-CH 2 O-等。 n表示0、1或2。这些化合物具有ORL1-受体拮抗剂活性。因此可用于治疗疾病或病症,例如疼痛,各种中枢神经系统疾病等。
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