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Derivatives of benzo (b) furane and benzo (b) thiophene, Pharmaceutical compositions containing them and their use in the manufacture of a Medicament for the treatment of diseases mediated by inhibition of the reabsorption of biogenic Amine neurotransmitters.
Derivatives of benzo (b) furane and benzo (b) thiophene, Pharmaceutical compositions containing them and their use in the manufacture of a Medicament for the treatment of diseases mediated by inhibition of the reabsorption of biogenic Amine neurotransmitters.
Pharmaceutical compositions containing them and their use in medicaments for the treatment of diseases mediated by inhibition of the serotonin 5-ht reuptake of noradrenaline (NA) and dopamine (DA).Claim 1: This refers to a compound represented by the General formula (1) in which u is o or s; R1 - R2 are independently selected from the group consisting of H, alkyd (ILO / in) - 6 cicloalqu C1, C3 (ILO) - 8, and in cicloalqu (C3) Il - 8 - alkyd (ILO / C1 - 6 in)Or R1 and R2 are jointly with the N that are united in a Ring of 4 - 7 members containing none or contains a double Bond, optionally comprising the Ring n Atom and the other selected R3 and R6 are selected, regardless of the group to the Ste in h, halogeno, cyano, alkyd (ILO / in) - 6 cicloalqu C1, C3 (ILO) - 8Cicloalqu (C3) and IL - 8 - alkyd (ILO / in) - 6 haloalqu (C1, C1 - 6 / in) ILO, ILO halocicloalqu (C3) and halocicloalqu - 8 (IL - 8) C3 - alkyd (ILO / in) 1 - 6; R7 is selected the Group consists of, alkyd (ILO / in) - 6 cicloalqu (C1, C3 and cicloalqu) ILO - 8 (IL - 8) C3 - alkyd (ILO / in C1) - 6 - (R8 R11 are selected; Regardless of the group consisting of H, halogeno, cyano, alkyd (ILO / C1 - 6 in)Cicloalqu (ILO) - 8 cicloalqu C3 (C3), IL - 8 - alkyd (ILO / in) - 6 haloalqu (C1, C1 - 6 / in) ilo (ILO, halocicloalqu) - 8 halocicloalqu C3 (C3), IL - 8 - alkyd (in / in) ILO C1 - 6, Nitro, amino, alkyd (C1 / in) Il - 6 - Di - (amino alkyd (C1 / IL - 6 in) amino) - cicloalqu (C3), IL - 8 - amino cicloalqu (C3), IL - 8 - alkyd (on / in il C1) - 6 - amino, hydroxyl alkyd (in / in) iloxilo C1 - 6, cicloalqu (C3) iloxilo - 8Cicloalqu (C3) Il - 8 - (on / in) iloxilo alkyd alkyd (C1 - 6, il / in) - 6 - sulfanilo C1, C3 cicloalqu (IL) - 8 - sulfanilo cicloalqu (C3) and IL - 8 - alkyd (C1 / in) Il - 6 - sulfanilo; m, n, o and P are independently 0 OR 1; X is selected from the group consisting chr12 CH2, and cr13r14; and Select Group Co In nsiste CH2, chr15 and cr16r17; Z is selected from the group consisting of CH2,Chr18 and cr19r20; and q is selected from the group consisting chr21 CH2, and cr22r23; where R12 - R23 is selected regardless of the group consisting of alkyd (ILO / in) - 6 cicloalqu (C1, C3 and cicloalqu) ILO - 8 (IL - 8) (C3 - alkyd in) ILO / C1 - 6; as the Free Base or a Salt thereof.
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机译：含有它们的药物组合物及其在药物中的用途，该药物用于抑制5-羟色胺（NA）和多巴胺（DA）的5-羟色胺的5-羟色胺再摄取介导的疾病。权利要求1：这是指由通式（1）表示的化合物）其中u是o或s; R 1 -R 2独立地选自H，醇酸（ILO 1 / in）-6 cicloalqu C1，C3（ILO）-8，和cicloalqu（C3）II-8醇酸（ILO / C1-6）或）R1和R2与N结合成一个4-7个成员的环，该成员不包含环或包含双键，可选地包含环n原子，并且选择其他选定的R3和R6，而不考虑基团到Ste in h，卤代，氰基，醇酸（ILO / in）-6 cicloalqu C1，C3（ILO）-8Cicloalqu（C3）和IL-8-醇酸（ILO / in）-6卤代醇（C1，C1 -ILO，ILO halocicloalqu（C3）和halocicloalqu（6 / in）-8（IL-8）C3-醇酸（ILO / in）1-6选择R7该组由以下组成：醇酸（ILO / in）-6环氯（C1，C3和cicloalqu）ILO-8（IL-8）C3-醇酸（ILO / in C1）-6-（R8 R11是选定;不考虑由H，卤代，氰基，醇酸组成的组（ILO / C1-6 in）Cicloalqu（ILO）-8 cicloalqu C3（C3），IL-8-醇酸（ILO / in）-6卤代醇（C1，C1-6-/ in）ilo（ILO，halocicloalqu）-8 halocicloalqu C3（C3），IL-8-醇酸（in / in）ILO C1-6，硝基，氨基，醇酸（C1 / in ）Il-6-二-（氨基醇酸（C1 // IL-6英寸）氨基）-环氯喹（C3），IL-8-氨基环氯酮（C3），IL-8-醇酸（在il C1中为 /） -6-氨基羟基醇酸醇酸树脂（in / in）伊洛西洛C1-6，cicloalqu（C3）iloxilo-8 Cicloalqu（C3）Il-8-（on // in）伊洛西洛醇酸树脂（C1-6，il / in ）-6-磺胺基C1，C3环氯（IL）-8-磺胺基环（C3）和IL-8-醇酸（C1 / in）II-6-磺胺; m，n，o和P独立为0或1 ; X选自chr12 CH2和cr13r14;和Select Group Co In n siste CH2，chr15和cr16r17; Z选自CH 2，Chr 18和cr 19r 20; q选自由hr21 CH2和cr22r23组成的组。其中选择R12-R23，而与醇酸（ILO // in）-6 cicloalqu（C1，C3和cicloalqu）组成的组无关，ILO-8（IL-8）（C3-醇酸in）ILO / C1-6;作为游离碱或其盐。
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