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Antigen arrays presenting IL-5, IL-13 or eotaxin for treatment of allergic eosinophilic diseases

机译:呈现IL-5,IL-13或嗜酸性粒细胞趋化因子的抗原阵列,用于治疗过敏性嗜酸性粒细胞疾病

摘要

Provided is a composition comprising a virus-like particle and at least one antigen or antigenic determinant, wherein said antigen or said antigenic determinant is a protein or peptide of IL-5, IL-I3 or eotaxin, and wherein said at least one antigen or antigenic determinant is bound to said virus-like particle. Further provided are such compositions comprising recombinant proteins or protein fragments from various human viruses, composition assembling to specific RNA phages, compositions comprising specific antigenic amino acid sequences. Further provided are corresponding pharmaceutical compositions and vaccines and methods of producing them.
机译:提供了一种包含病毒样颗粒和至少一种抗原或抗原决定簇的组合物,其中所述抗原或所述抗原决定簇是IL-5,IL-13或嗜酸性粒细胞趋化因子的蛋白质或肽,并且其中所述至少一种抗原或抗原抗原决定簇与所述病毒样颗粒结合。还提供了这样的组合物,其包含来自各种人类病毒的重组蛋白或蛋白片段,组合成特定RNA噬菌体的组合物,包含特定抗原性氨基酸序列的组合物。还提供了相应的药物组合物和疫苗及其生产方法。

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