New pharmaceutical compositions (A) contain 0.01-20 (preferably 0.11-20, especially 0.5-5) wt. % beard lichen ( Usnea barbata) extract (I) and 0.01-80 (preferably 0.11-20, especially 0.5-5) wt. % St. John's wort ( Hypericum perforatum) extract (II). ACTIVITY : Antiseborrheic; Dermatological; Vulnerary; Antiinflammatory; Antibacterial; Fungicide; Antipsoriatic. MECHANISM OF ACTION : UV-induced collagenase activation inhibitor; UV-induced prostaglandin E 2 synthesis inhibitor. In tests in primary human fibroblast cultures, the active collagenase (MMP-1) content (initially ca. 3.0 ng/ml) was increased to ca. 8.0 ng/ml by UVA-1 irradiation (60 J/cm 2) to ca. 8 ng/ml; and on subsequent incubation for 24 hours with Usnea barbata extract (0.1 v/v) or a combination of the Usnea barbata extract (0.1 v/v) and Hypericum perforatum extract (0.1 v/v) was reduced to ca. 5.2 ng/ml or ca. 0.8 ng/ml respectively.
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机译：新的药物组合物（A）包含0.01-20（优选0.11-20，特别是0.5-5）重量％。 ％的胡子地衣（松萝）提取物（I）和0.01-80（优选0.11-20，尤其是0.5-5）wt。 ％圣约翰草（贯叶连翘）提取物（II）。活动：抗脂溢性;皮肤;伤药;消炎（药;抗菌;杀菌剂对牛皮癣。作用机理：紫外线诱导的胶原酶活化抑制剂。紫外线诱导的前列腺素E 2合成抑制剂。在原代人成纤维细胞培养物中进行的测试中，活性胶原酶（MMP-1）含量（最初约为3.0 ng / ml）增加到了约200 ng / ml。通过UVA-1照射（60J / cm 2）至约8.0ng / ml。 8 ng / ml;随后与半球形松萝提取物（0.1 v / v）或半球形松萝提取物（0.1 v / v）和贯叶连翘提取物（0.1 v / v）的混合物一起孵育24小时后，其还原度约为。 5.2 ng / ml或大约分别为0.8 ng / ml。
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