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MIXED OLANZAPINE SOLVATE, METHOD FOR THE PRODUCTION AND METHOD FOR THE PRODUCTION OF OLANZAPINE FORM I THEREOF
MIXED OLANZAPINE SOLVATE, METHOD FOR THE PRODUCTION AND METHOD FOR THE PRODUCTION OF OLANZAPINE FORM I THEREOF
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机译:混合的奥氮嗪溶剂化物,其制备方法和制备形式的奥氮嗪的方法
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摘要
Said mixed solvate is a solvate of olanzapine/water/tetrahydrofuran in the proportion 1:1:1/2 (I). The method for preparing said solvate comprises treating a crude anhydrous olanzapine with a mixture of tetrahydrofuran/water. The method for preparing Form I of olanzapine includes desolvating the mixed solvate of formula I, by means of drying, in vacuo and under temperature-controlled conditions.
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