(3R)-HYDROXYACYL-ACP DEHYDRATASE ENZYMES INVOLVED IN THE BIOSYNTHESIS OF MYCOLIC ACIDS AND USE OF SAME FOR SCREENING ANTIBIOTICS

摘要

The invention relates to (3R)-hydroxyacyl-ACP dehydratase enzymes involved in the biosynthesis of mycolic acids, and to the use of same for screening antibiotics, medicaments that can be used to treat infections in humans or in animals, caused by Corynebacterineae, more specifically infections caused by pathogenic mycobacteria (Mycobacterium tuberculosis, M. africanum, M. leprae, M. ulcerans, M. microti, M. bovis, M. abscissus, M. avium, M. fortuitum, M. kansasii...), and infections caused by other genera such as Nocardia, Rhodococcus, Gordona...