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Agents for treating intraocular inflammation caused by irradiation with lasers, containing 1,4-dihydropyridine derivatives

机译:含有1,4-二氢吡啶衍生物的治疗激光照射引起的眼内炎症的药物

摘要

The present invention provides a 1,4-dihydropyridine derivative of the formula (I)wherein X1 and X2 are the same or different and each is hydrogen atom, fluoromethyl, fluoromethoxy, halogen, cyano or nitro, R1 is lower alkyl, R2 is acyl, alkoxycarbonyl, acylalkyl, N-alkyl-substituted carbamoylalkyl, alkoxyalkyl, alkoxycarbonylalkyl, acyloxyalkyl, nitratoalkyl, cyanoalkyl, hetero ring-alkyl, haloalkyl, alkenyl or alkynyl, A is alkylene having a carbon atom bonded with two alkyls and 5 or more carbon atoms in total, and m is an integer of 1 to 3,or an acid addition salt thereof, and a medicament containing said compound of formula (I) as an active ingredient for topically treating intraocular inflammation caused by laser irradiation.
机译:本发明提供式(I)的1,4-二氢吡啶衍生物 <图像文件=“ IMGA0001.GIF” he =“ 52” imgContent =“ chem” imgFormat =“ GIF” wi =“ 109” /> 其中X 1 和X 2 相同或不同,分别为氢原子,氟甲基,氟甲氧基,卤素,氰基或硝基,R 1 是低级烷基,R 2 是酰基,烷氧基羰基,酰基烷基,N-烷基取代的氨基甲酰基烷基,烷氧基烷基,烷氧基羰基烷基,酰氧基烷基,硝酸根烷基,氰基烷基,杂环烷基,卤代烷基,烯基或炔基,A是碳原子总数为2个且碳原子数为5以上的碳原子的亚烷基,m为1〜3的整数,或其酸加成盐,以及含有所述式(I)化合物作为活性成分的药物,用于局部治疗由激光照射引起的眼内炎症。

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