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RECOMBINANT ADENOVIRUS EXPRESSING A GENE ENCODING STREPTOLYSIN O PROTEIN AND ANTI-CANCER COMPOSITION COMPRISING SAME
RECOMBINANT ADENOVIRUS EXPRESSING A GENE ENCODING STREPTOLYSIN O PROTEIN AND ANTI-CANCER COMPOSITION COMPRISING SAME
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机译:重组腺病毒表达基因编码链球菌溶血素蛋白和抗癌组合物
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摘要
A recombinant adenovirus expressing a streptolysin O (SLO) protein comprising a SLO gene; a promoter operably linked to the SLO gene; a polyadenylation signal sequence; and an adenovirus genome lacking E1 gene effectively kills a cancer cell by expressing a pore-forming toxin, SLO protein, and, therefore, is useful for the suicide cancer gene therapy.
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