DUAL-EXPOSURE CHAMBER MEANS AND APPARATUS FOR THE ASSESSMENT OF NANO-PARTICLE INHALATION TOXICITY COMPOSED THEREOF

摘要

A double exposure chamber tool and an apparatus for evaluating the nano-particle inhalation toxicity are provided to evaluate the inhalation toxicity more accurately by preventing an inhaled gas of a tested animal from being flown in, allow mouse to breath smoothly by inhibiting the flow velocity of a tested material through inhalation of the mouse and prevent a tester from being directly exposed to the tested material during the inhalation toxicity test. A double exposure chamber tool(200) comprises an outer chamber member(210) in which a front side portion is opened, a rear side portion is formed to be a closely sealed hollow cylindrical shape, a plurality of outer chamber material outlets is formed at the rear side portion by penetrating therethrough, a plurality of mouse holder binding holes is formed at both sides of a side by penetrating therethrough to be faced to one another and three measuring holes(213) is formed at the upper portion of the side by penetrating therethrough; an outer chamber stopper member(220), one end of which is coupled to the front side portion of the outer chamber member and in which a material inlet is formed at the other end by penetrating therethrough; an inner chamber member which is bound to the inside of the outer chamber member and of which a front side portion is opened, a rear side portion is formed to be closely sealed hollow cylindrical shape, a plurality of inner chamber material outlets is formed at the rear side portion by penetrating therethrough and a plurality of mouse holder binding holes is formed at both sides of a side by penetrating therethrough to be faced to one another; a perforated plate member which is bound to the front side portion of the inner chamber member and is a thin plate shape where a plurality of through holes is formed; and a plurality of mouse holder members(250) which is bound to the mouse holder binding hole of the outer chamber member and in which an animal to be tested for evaluating nano-particle inhalation toxicity is input. An apparatus for evaluating the nano-particles inhalation toxicity of an animal to be tested comprises a multi-layered chamber in which a material inlet and a material outlet are formed at both ends of a parallel space member; and a plurality of double exposure chamber tool.