ELUTION OF FLUORINE-18 FLUORIDE FROM ANION EXCHANGE POLYMER SUPPORT CARTRIDGE USING PROTIC SOLVENTS WHICH DISSOLVE SALT IN AND ITS APPLICATION OF FLUORINE-18 FLUORINATION METHOD

摘要

A method for labeling fluorine-18 in alkyl halides or alkyl sulfonates is provided to reduce the overall time required for carrying out labeling of fluorine-18, and to obtain a labeled compound with high purity and high yield. A method for labeling fluorine-18 comprises the steps of: (i) adsorbing [18F] fluoride onto a quaternary ammonium-supported polymer support; (ii) eluting the [18F]fluoride adsorbed in step (i) with an ammonium salt represented by the following formula 2 or a solution containing a metal salt dissolved in an alcohol solvent represented by the following formula 1; and (iii) reacting the [18F]fluoride eluted in step (ii) with an alkyl halide or alkyl sulfonate in the presence of a reaction solvent to perform fluorine-18 labeling. In formula 1, each of R1, R2 and R3 is H or a C1-C8 alkyl. In formula 2, R4 is H or a C1-C5 primary or secondary alkyl group; and X- is -OH, -OTf, -OMs, HCO3^-, CO3^2-,H2PO4^-,HPO4^2- or PO4^3-.