5¥á-Reductase Inhibitors, Abietic Acid from Resina Pini of Pinus spp.

摘要

The present invention is derived from pine trees pine resin 5-alpha-reductase related to abietic acid for inhibitors. 50% ethanol extract of pine resin extracted from pine trees (Pinaceae) are androgens, such as benign prostatic hyperplasia - prepared from rat prostate than extracts of some plants that are used in the treatment of diseases dependent 5 alpha- exhibited potent inhibitory activity against the reductase . After purification of the fractions and remove the cause of the activity of the active ingredient, were identified as di-terpene resin acids of abietic acid, a powerful 5-alpha-reductase inhibitory activity naeteotda that the hydratase. Tate is a 5-alpha-methyl father than abietic acid-reductase was substantially inert to the matriptase, whereas the other di terpene resin acids Avoid dry mountains and neo-abietic acid 5-alpha-like activity were never abietic acid against reductase , which represents an important structural part the anionic carboxyl groups on the molecule is negatively charged showing the inhibitory activity. This finding nonsteroidal compounds of natural origin with the anionic acid moiety is androgen-implies that may have potential as highly simplified transition state inhibitors for the treatment of similar diseases dependent