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MULTIPARTICULAR ARZNEIFORM, CONTAINING MUCOADHAESIVE FORMULATED PEPTID OR PROTEIN ACTIVITIES, AND A PROCEDURE FOR PREPARING ARZNEIFORM
MULTIPARTICULAR ARZNEIFORM, CONTAINING MUCOADHAESIVE FORMULATED PEPTID OR PROTEIN ACTIVITIES, AND A PROCEDURE FOR PREPARING ARZNEIFORM
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机译:包含粘胶形式的肽或蛋白质活性的多颗粒阿兹尼形药物,以及制备阿兹尼形药物的方法
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摘要
The invention relates to an oral, multiparticle pharmaceutical dosage form containing pellets, the size of which ranges from 50 to 2500 m and which essentially consist of: a) an inner matrix layer containing an active substance which is a peptide or a protein, including the derivatives or conjugates thereof, and which is embedded in a matrix consisting of a polymer with mucoadhesive effect, and b) an outer film coating essentially consisting of an anionic polymer or copolymer, which can be optionally formulated with pharmaceutically conventional adjuvants, more particularly softening agents.
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