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Itraconazole formulation for oral administration
Itraconazole formulation for oral administration
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机译:伊曲康唑口服制剂
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摘要
PROBLEM TO BE SOLVED: To develop an itraconazole preparation having a high biological utilization factor, by improving dissolubility of the itraconazole in a gastric digestive juice comprising an acidic liquid.;SOLUTION: This itraconazole preparation for oral administration is produced by spraying/coating fine particles having an average particle diameter of 10-60 m as nuclear particles with a mixture solution of the itraconazole and an enteric polymer, and then controlling an average particle diameter of an obtained coated powder to be 50-120 m. Thus, the preparation which is improved in the dissolubility in the gastric digestive juice is produced.;COPYRIGHT: (C)2006,JPO&NCIPI
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