Bis (arylmethylidene) acetone compound, anticancer agent, carcinogenesis preventive agent, Ki-Ras, ErbB2, c-Myc and CyclinD1 expression inhibitor, β-catenin degrading agent and p53 expression enhancer

摘要

There is a need for the development of antitumor active compounds that improve the properties of curcumin, which has poor solubility, and control the growth of various cancers at low concentrations. Provided are novel synthetic compounds bis (arylmethylidene) acetones which have excellent antitumor activity and also have carcinogenesis preventing activity. Anti-tumor activity and carcinogenesis-preventing activity by newly synthesizing and screening derivatives bis (arylmethylidene) acetones that are based on curcumin, a compound with anti-tumor activity and also having carcinogenesis-preventing activity. Can be synthesized.